extracts from a scientific publication

Effects of PENAC-T on the Biological Regulation and Pork Production

Faculty of Veterinary Medicine and Animal Resource Research Center,

Kon-Kuk University, Seoul 143-701, Korea

(Received April 22, 1998 : Accepted May 6, 1998)


The study aimed to see the effect of penac-t on the body weight gain, rate of carcass yield, grade and feed conversion of landrace pigs. To do this, productivity of nitric oxide (NO) and immunity augmentation of penac-t were observed in mouse macrophage-derived cell line. Also the growth of vascular smooth muscle cells were examined in the experiment of smooth muscle contraction of blood vessels. These experiments were focused to see the drug resistance effect of penac-t, and to analyze the growth mechanism by which penac-t would promote body weight increment of the domestic animal.

The results are as follows:-

A group was raised with penac-t in the feed and a control group with Bambermycin plus Olakwydox. The growth effect, daily weight gain, dressing percentage and feed conversion were compared between the two groups. The penac-t group showed to some extent higher effects in the above criteria and had significantly more pigs with grade A and B carcass yield than the control group (p<0.05). The result indicates that the use of penac-t as a potential feed additive may help to produce safe pork, without antibiotics and hormones.

To investigate the mechanism of productivity promotion, macrophage-derived cell line (Raw 264.7) was treated with penac-t and NO productivity was observed. NO production was started at the concentration of 5g / ml of penac-t and the peak was shown at the concentration of 50g / ml (p<0.01). Nearly no inhibiting activity of cell growth was observed.

To see if cell growth is promoted, vascular smooth muscle cells (VSMS) were treated for 24 hours with various concentrations of penac-t. The effect of the cell growth rate showed peaks at the concentration of 2.5 and 5.0g / ml (p<0.05). When observing the effect of penac-t, a small amount of NO was released over a long period of time, it thereby had an effect on the immune cells without great damage to neighbouring cells.

These results suggest that penac-t is effective in producing disease resistant pigs.